Dizziness in the emergency department: it is not always stroke or vestibular neuritis

For Healthcare Professionals:

Patients presenting to the emergency department with newly developed vertigo, dizziness, or gait instability are usually evaluated according to the classic framework of “stroke versus acute unilateral vestibulopathy (AUVP).” However, a recent review by Lee et al. shows that up to 50% of these acute cases have a completely different cause, often medical/internal medicine-related or non-ischemic in nature.

🔗 Lee SU, Edlow JA, Tarnutzer AA. Acute Vertigo, Dizziness and Imbalance in the Emergency Department—Beyond Stroke and Acute Unilateral Vestibulopathy—A Narrative Review. Brain Sci. 2025.

Original study on PubMed

The underestimated breadth of acute vestibular syndrome (AVS)

Acute dizziness and sudden gait disturbances are among the most common symptoms in emergency departments and account for approximately 2.1 to 4.4% of all cases. The major challenge is that around half of these patients have an underlying systemic disease that does not primarily originate from the cerebral blood vessels (stroke) or the vestibular organ in the inner ear (AUVP). This means that the spectrum of causes of a true AVS is far broader than the two classic diagnoses. Approximately 15% of these internal medicine-related and medication-related causes are potentially life-threatening, but are highly treatable if diagnosed in time.

Dangerous neurological causes (beyond stroke)

When the cause lies in the central nervous system, it does not necessarily have to be a cerebral infarction or a brain hemorrhage. The following conditions can trigger a true acute vestibular syndrome:

• Wernicke encephalopathy (thiamine/vitamin B1 deficiency): This neurological emergency occurs acutely after prolonged vomiting, for example during pregnancy, malnutrition, or chronic alcohol abuse. Typical features include marked gait instability and subtle eye movement abnormalities, such as an initially upward-beating and later downward-beating nystagmus, or gaze-evoked nystagmus. 

-> Clinical practice tip: If there is justified suspicion, high-dose thiamine (200–500 mg three times daily) must be administered intravenously immediately, even before laboratory results are available.

• Demyelinating diseases, such as multiple sclerosis: Acute MS plaques in the brainstem region or at the entry zone of the vestibular nerve fiber can trigger an acute vestibular syndrome with central ocular signs.
• Space-occupying lesions of the posterior fossa: Benign or malignant tumors, such as brainstem gliomas or cerebellar metastases, can directly compress the central vestibular pathways. When tumor growth exceeds the brain’s compensatory mechanisms or surrounding edema develops, dizziness, gait ataxia, and vomiting can begin suddenly or worsen dramatically, which can then clinically appear, incorrectly, like an acute stroke.
• Vestibular migraine: The very first severe vertigo attack of vestibular migraine is frequently misinterpreted as a stroke in the acute setting. Cases have been documented in the medical literature in which patients mistakenly received intravenous thrombolysis, a powerful medication used to dissolve blood clots, because the symptoms could not be properly distinguished.

Dangerous non-neurological causes

If affected patients do not have eye jerking movements (nystagmus) and the symptoms do not worsen markedly with head movements, internal medicine-related triggers become more likely:

• Medication intoxication: Excessively high therapeutic levels of centrally acting medications such as antiepileptic drugs (phenytoin, carbamazepine, oxcarbazepine) or lithium can trigger severe acute dizziness and coordination disorders.
• Cardiovascular emergencies: Acute cardiac arrhythmias, myocardial infarction, pulmonary embolism, or life-threatening aortic dissection can lead to acute dizziness through a sudden drop in blood pressure and cardiac output.
• Electrolyte disturbances and metabolic derangements: Marked sodium deficiency (hyponatremia), severe magnesium deficiency (hypomagnesemia — often associated with downbeat nystagmus), or an acute drop in blood glucose (hypoglycemia) must be ruled out by laboratory testing.

Important for clinical practice (decompensation): Acute physical stressors such as high fever, infections, dehydration, or oxygen deficiency can suddenly make an old vestibular organ injury, which the brain had actually long since compensated for well, become apparent again, for example after vestibular neuritis years earlier. The affected patients decompensate and appear in the emergency department as if they have an acute medical emergency.

The structured path to diagnosis: TiTrATE

To quickly move in the right diagnostic direction during the hectic routine of the emergency department, the systematic TiTrATE concept is helpful:

1. Timing (How long have the symptoms been present? Did they begin suddenly or gradually?)
2. Triggers (Are the episodes triggered by specific stimuli such as head positioning or standing up quickly?)
3. And Targeted Examination (Gezielte Untersuchung: Durchführung des HINTS-Tests zur Schlaganfalldiagnostik, gezielte Lagerungsprüfung sowie eine genaue Stand- und Gangprüfung).

👉 Are you interested in a comprehensive further training in vestibular rehabilitation and how to correctly interpret the clinical signs of these complex causes of dizziness and how to rehabilitate affected patients safely and in a targeted way after the acute phase? 

Current further education opportunities and course dates can be found in the IVRT Course search.

For Patients – Easy to Understand

Dizziness in the emergency department: it is not always stroke or vestibular neuritis

When someone suddenly develops severe spinning vertigo, has to vomit repeatedly, and can barely stand, the next stop is usually the emergency department. The biggest concern is almost always: Is it a stroke? Or is the inner ear inflamed?

However, a large medical review shows that in almost half of all patients, acute dizziness has a completely different cause located elsewhere in the body.

📄 Lee SU, Edlow JA, Tarnutzer AA. Acute Vertigo, Dizziness and Imbalance in the Emergency Department—Beyond Stroke and Acute Unilateral Vestibulopathy—A Narrative Review. Brain Sci. 2025.

Original study

Here is a simple overview of what may be responsible — apart from stroke and the ear:

1. Problems in the brain that are not a stroke

The brain controls our balance. But it can also be disrupted by other acute problems:

• A sudden, severe vitamin deficiency (vitamin B1): If someone has been vomiting severely for days, for example during pregnancy, or is very poorly nourished, the brain can quickly lack important nutrients. This leads to severe dizziness, visual disturbances, and extreme unsteadiness when walking. The good news: If the vitamin is given quickly as an injection or infusion, the brain usually recovers rapidly.
• Multiple sclerosis (MS): If a new inflammatory MS lesion develops exactly where the balance nerves enter the brain, it can trigger severe dizziness from one moment to the next.
• Lumps or swelling (tumors): If a tumor grows in the back part of the head, it may eventually press on the balance pathways. This can cause dizziness and nausea to suddenly become much worse.
• Vestibular migraine: This is a type of migraine that does not cause headache, but severe dizziness. People who experience it for the first time often end up in hospital in great panic because it feels exactly like a stroke.

2. Problems that are not located in the brain (medical/internal causes)

Sometimes the balance organs and the brain are completely healthy, but another problem in the body interferes with them:

• Side effects of medication: Certain tablets, especially those used for seizures, severe pain, or sedation, can suppress the brain so strongly that a person becomes persistently dizzy if the dose is too high.
• Cardiovascular emergencies: If the heart suddenly starts beating irregularly, if someone is having a heart attack, or if there is a clot in the lung (pulmonary embolism), blood pressure drops. The brain receives too little blood for a moment and immediately signals: dizziness!
• Abnormal salt levels in the blood: After a severe gastrointestinal infection, a person may lose too much fluid and important body salts, such as sodium or magnesium. This disrupts the body’s entire electrical system and can cause extreme dizziness and shakiness.

3. The mystery of “reactivated” dizziness

A very common reason for emergency department visits is what is known as decompensation. This means: Perhaps you had inflammation of the balance nerve years ago. At the time, your brain learned to compensate for that damage.

But if you now develop a high fever, a severe infection, or extreme dehydration, your brain becomes overloaded. It can no longer maintain the compensation. The old dizziness suddenly flares up again and feels like a brand-new emergency, even though nothing new has happened in the ear.

What can you do?

In der Notaufnahme versuchen die Ärzt:innen mit einem festen System (TiTrATE) herauszufinden, was los ist: Sie fragen nach der Dauer (Timing) und den Auslösern (Triggers) und untersuchen deine Augen und deinen Gang (And Targeted Examination).

You can help the team most if you have the following ready:

1. An up-to-date medication list.
2. Information about whether you had been fasting, had a fever, or had been vomiting for days beforehand.
3. Precise information about whether the dizziness came on by itself while lying down, or only when you moved your head or stood up.

🎯 Our IVRT®-certified dizziness and vestibular therapists support you: Once the doctors in the emergency department have ruled out dangerous causes, we can help you. With targeted, scientifically validated movement exercises, we teach your brain to work steadily again so that you can regain your safety in everyday life. Find qualified help near you: IVRT therapist search